Hydromorphones

Hydromorphones

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Hydromorphone is an opioid medication used to treat moderate to severe pain. The extended-release form of hydromorphone is for around-the-clock treatment of moderate to severe pain, not for use on an as-needed basis for pain. how ever Hydromorphone may also be used for purposes not listed in this medication guide.

more to that, Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is an opioid used to treat moderate to severe pain. Typically, long-term use is only recommended for pain due to cancer. It may be used by mouth or by injection into a vein, muscle, or under the skin.

Therefor we can say that Hydromorphone metabolites were found in plasma, urine and human hepatocyte test systems. There are no indications to hydromorphone being metabolised in vivo via the cytochrome P 450 enzyme system. In vitro, hydromorphone has but a minor inhibition effect (IC50 > 50 μM) on recombinant CYP isoforms, including CYP1A2, 2A6, 2C8, 2D6 und 3A4 .

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